Derek J. Chadwick

The use of oligonucleotides as therapeutic agents rests upon their ability to interfere, in a sequence-specific manner, with the fundamental machinery…

Drawing together contributions from a diverse group of international experts in the field, this collection of papers examines the biology and patholog…

Osteoarthritis is a chronic degenerative disease associated with joint pain and loss of joint function. It has an estimated incidence of 4 out of ever…

An interdisciplinary and multinational group of specialists present contributions describing the current status of vaccines against virally induced tu…

A comprehensive review of current thinking on the biosynthesis, function and evolution of secondary metabolites in animals, plants and microorganisms.…

T cells are a specialized population of immune cells that aid the immune system in combating various types of invading pathogens. This book presents u…

Epigenetics pertains to the development of an organism from an undifferential cell, resulting in the successive formation and development of organs an…

Using a multidisciplinary approach, it combines anatomical, cellular and physiological studies by preeminent experts. Features important insights into…

The pacemaking and conduction system (PCS) is vital for generating and synchronizing the heart beat. Dysfunction of this system can be a direct cause …

How the amino acid sequence of a protein determines its three-dimensional structure is a major problem in biology and chemistry. Leading experts in th…

The heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila. This was later related to the appearance of n…

The field of neural transplantation is at a crucial stage, with important clinical trials on transplantation in patients with Parkinson's disease near…

Using a multidisciplinary approach, it combines anatomical, cellular and physiological studies by preeminent experts. Features important insights into…

Useful throughout history for their medical as well as other benefits, plant-derived compounds have gained particular importance recently, due to envi…

This book draws together contributions from cell and developmental biologists, structural biologists, geneticists and clinical scientists aimed at a b…

Prominent contributors address issues regarding the toxicity of aluminum which causes an encephalopathy in renal dialysis patients and is also known t…

As part of a continuing effort to tackle issues of major social concern, this 280th conference of internationally recognized experts from the fields o…

Chronic inflammation predisposes to some forms of cancer and the host response to malignant disease shows several parallels with inflammation and woun…

Part of the prestigious Novartis Foundation, this is the first book to review the pathology associated with acetaldehyde, a known toxic agent found in…

This book brings together contributions from key investigators in the area of pathological pain. It covers the molecular basis of receptors and channe…

This exciting book brings together an international and interdisciplinary group of experts to discuss the importance of pulsatile signalling in the in…

The book presents recent advances relating to the factors and mechanisms that regulate the growth, differentiation and function of mast cells and baso…

Asthma is a growing health problem throughout the developed world. This volume presents a critical review of all the possible factors for this rising …

Recent application of the techniques of molecular biology and patch-clamp physiology has led to rapid advances in understanding the molecular events i…

Smooth muscle contraction is a vital component of the functioning of blood vessels, the uterus, airways and the bladder. Its malfunction can lead to s…

Gramicidin channels have been studied intensively for more than 25 years. They serve as model transport systems for large protein ion channels, since …

A number of chronic respiratory diseases including chronic bronchitis, asthma, cystic fibrosis and bronchiectasis are characterized by mucus hypersecr…

Contains the presentations and discussions that took place during a symposium at the CIBA Foundation on October 1-3, 1990 on the subject of catalytic …