Hugo Kubinyi

Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for can…

Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in …

This first systematic overview for more than a decade is tailor-made for the medicinal chemist. All the chapters are written by experienced drug devel…

In this comprehensive two-volume resource on the topic senior lead generation medicinal chemists present a coherent view of the current methods and st…

This handbook is the first to address the practical aspects of this novel method. It provides a complete overview of the field and progresses from gen…

From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often …

By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critica…

This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications fro…

The vast progress made in the investigation of biomolecules using NMR has only recently been rewarded with the Nobel Prize for Kurt Wuthrich. Edited b…

Most drugs bind to a clearly defined macromolecular target that is complementary in terms of structure and chemistry. This observation is the basic pa…

In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment…

Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by …

Barrier, reservoir, target site – those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with th…

The authors of this guide are experts on the use of microwaves for drug synthesis as well as having much experience in teaching courses held under the…

Quantitative studies on structure-activity and structure-property relationships are powerful tools in directed drug research. In recent years, various…

This one-stop reference is the first to present the complete picture – covering all relevant organisms, from single cells to mammals, as well as all m…

As we enter the new millennium, combinatorial chemistry is providing significant impetus to new innovations in synthetic chemistry. Combinatorial chem…

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such…

With its particular emphasis on the constitutive activity of G-protein-coupled receptors (GPCRs)s, this book comprehensively discusses an important bi…

Computational methods are transforming the work of chemical and pharmaceutical laboratories. Increasingly faster and more exact simulation algorithms …

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the larges…

Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with a review of the first wave of phosphodiesterase (PDE) inhi…

Tailored to the needs of scientists developing drugs, chemicals, cosmetics and other products this one-stop reference for medicinal chemists covers al…

Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, includin…

The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life …

This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the…

Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemo…

Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for develop…

This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and…

This unique reference source, edited by the world's most respected expert on molecular interaction field software, covers all relevant principles of t…

Written for drug developers rather than computer scientists, this monograph adopts a systematic approach to mining scientifi c data sources, covering …

Tailored to the needs of medicinal and natural products chemists, the second edition of this unique handbook brings the contents up to speed, almost d…

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integ…

Recent progress in high-throughput screening, combinatorial chemistry and molecular biology has radically changed the approach to drug discovery in th…

The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The …

The first professional reference on this highly relevant topic, for drug developers, pharmacologists and toxicologists. The authors provide more than …

The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated …

In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part pr…

When trying to find new methods and problem-solving strategies for their research, scientists often turn to nature for inspiration. An excellent examp…

Written by experienced experts in molecular modeling, this books describes the basics to the extent that is necessary if one wants to be able to relia…

The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by exp…

The number-one reference on the topic now contains a wealth of new data: The entire relevant literature over the past six years has been painstakingly…

This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previ…

Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, inc…

This practice-oriented handbook surveys current knowledge on the prediction and prevention of adverse drug reactions related to off-target activity of…