David Machin

This book provides statisticians and researchers with the statistical tools – equations, formulae and numerical tables – to design and plan clinical s…

The assessment of patient reported outcomes and health-related quality of life continue to be rapidly evolving areas of research and this new edition …

The same careful rigour imposed on the design of phase III randomised controlled trials is not always applied to medical research in other areas such …

[i]Randomised Clinical Trials: Design, Practice and Reporting[/i] provides a detailed overview of the methodology for conducting clinical trials, incl…

The 5th edition of this popular introduction to statistics for the medical and health sciences has undergone a significant revision, with several new …

Well received in its first edition, Survival Analysis: A Practical Approach is completely revised to provide an accessible and practical guide to surv…

All new medicines and devices undergo early phase trials to assess, interpret and better understand their efficacy, tolerability and safety. An Introd…

Now published in its Second Edition, the Textbook of Clinical Trials offers detailed coverage of trial methodology in diverse areas of medicine in a s…

This highly popular introduction to confidence intervals has been thoroughly updated and expanded. It includes methods for using confidence intervals,…

Quality of life studies form an essential part of the evaluation of any treatment. Written by two authors who are well respected within this field, Qu…