Hugo Kubinyi

In keeping with the outstanding importance of lipophilicity in biosciences, this volume examines all its facets in more than twenty contributions from…

Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in …

This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications fro…

This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previ…

The vast progress made in the investigation of biomolecules using NMR has only recently been rewarded with the Nobel Prize for Kurt Wuthrich. Edited b…

From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often …

By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critica…

Barrier, reservoir, target site – those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with th…

Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, inc…

The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structure…

In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment…

Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by …

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such…

The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life …

Computational methods are transforming the work of chemical and pharmaceutical laboratories. Increasingly faster and more exact simulation algorithms …

This one-stop reference is the first to present the complete picture – covering all relevant organisms, from single cells to mammals, as well as all m…

As we enter the new millennium, combinatorial chemistry is providing significant impetus to new innovations in synthetic chemistry. Combinatorial chem…

Tailored to the needs of scientists developing drugs, chemicals, cosmetics and other products this one-stop reference for medicinal chemists covers al…

The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The …

This readily comprehensible book explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as…

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the larges…

Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with a review of the first wave of phosphodiesterase (PDE) inhi…

Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for develop…

Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for can…

Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, includin…

This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the…

Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemo…

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integ…

When trying to find new methods and problem-solving strategies for their research, scientists often turn to nature for inspiration. An excellent examp…

Written by experienced experts in molecular modeling, this books describes the basics to the extent that is necessary if one wants to be able to relia…

Written for drug developers rather than computer scientists, this monograph adopts a systematic approach to mining scientifi c data sources, covering …

Tailored to the needs of medicinal and natural products chemists, the second edition of this unique handbook brings the contents up to speed, almost d…

In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part pr…

This practice-oriented handbook surveys current knowledge on the prediction and prevention of adverse drug reactions related to off-target activity of…

In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing a…

The first professional reference on this highly relevant topic, for drug developers, pharmacologists and toxicologists. The authors provide more than …

The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated …

With its particular emphasis on the constitutive activity of G-protein-coupled receptors (GPCRs)s, this book comprehensively discusses an important bi…

In this comprehensive two-volume resource on the topic senior lead generation medicinal chemists present a coherent view of the current methods and st…

The authors of this guide are experts on the use of microwaves for drug synthesis as well as having much experience in teaching courses held under the…

The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by exp…

The number-one reference on the topic now contains a wealth of new data: The entire relevant literature over the past six years has been painstakingly…

Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and…

This unique reference source, edited by the world's most respected expert on molecular interaction field software, covers all relevant principles of t…

The new edition of this practice-oriented handbook features thoroughly updated contents, including recent developments in parallel synthesis. A new ch…