Derek J. Chadwick

Many different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions…

This book draws together contributions from cell and developmental biologists, structural biologists, geneticists and clinical scientists aimed at a b…

This book brings together contributions from key investigators in the area of pathological pain. It covers the molecular basis of receptors and channe…

Contains the presentations and discussions that took place during a symposium at the CIBA Foundation on October 1-3, 1990 on the subject of catalytic …

T cells are a specialized population of immune cells that aid the immune system in combating various types of invading pathogens. This book presents u…

The use of oligonucleotides as therapeutic agents rests upon their ability to interfere, in a sequence-specific manner, with the fundamental machinery…

Epigenetics pertains to the development of an organism from an undifferential cell, resulting in the successive formation and development of organs an…

As part of a continuing effort to tackle issues of major social concern, this 280th conference of internationally recognized experts from the fields o…

Chronic inflammation predisposes to some forms of cancer and the host response to malignant disease shows several parallels with inflammation and woun…

Asthma is a growing health problem throughout the developed world. This volume presents a critical review of all the possible factors for this rising …

An interdisciplinary and multinational group of specialists present contributions describing the current status of vaccines against virally induced tu…

A comprehensive review of current thinking on the biosynthesis, function and evolution of secondary metabolites in animals, plants and microorganisms.…

How the amino acid sequence of a protein determines its three-dimensional structure is a major problem in biology and chemistry. Leading experts in th…

The pacemaking and conduction system (PCS) is vital for generating and synchronizing the heart beat. Dysfunction of this system can be a direct cause …

This exciting book brings together an international and interdisciplinary group of experts to discuss the importance of pulsatile signalling in the in…

Using a multidisciplinary approach, it combines anatomical, cellular and physiological studies by preeminent experts. Features important insights into…

The field of neural transplantation is at a crucial stage, with important clinical trials on transplantation in patients with Parkinson's disease near…

Recent application of the techniques of molecular biology and patch-clamp physiology has led to rapid advances in understanding the molecular events i…

Prominent contributors address issues regarding the toxicity of aluminum which causes an encephalopathy in renal dialysis patients and is also known t…

This volume examines obesity disorders which can lead to diabetes, hypertension and hyperlipidaemia. It offers an interdisciplinary and international …

Using a multidisciplinary approach, it combines anatomical, cellular and physiological studies by preeminent experts. Features important insights into…

Part of the prestigious Novartis Foundation, this is the first book to review the pathology associated with acetaldehyde, a known toxic agent found in…

ATP, the intracellular energy source, is also an extremely important cell–cell signalling molecule for a wide variety of cells across evolutionarily d…

A number of chronic respiratory diseases including chronic bronchitis, asthma, cystic fibrosis and bronchiectasis are characterized by mucus hypersecr…

The book presents recent advances relating to the factors and mechanisms that regulate the growth, differentiation and function of mast cells and baso…

Oxygen sensing is a key physiological function of many tissues, but the identity of the sensor, the signalling pathways linking the sensor to the effe…

Osteoarthritis is a chronic degenerative disease associated with joint pain and loss of joint function. It has an estimated incidence of 4 out of ever…

Smooth muscle contraction is a vital component of the functioning of blood vessels, the uterus, airways and the bladder. Its malfunction can lead to s…